In the 1990s, Swiss medical experts found that platelets can produce a large number of growth factors at high concentrations, which can quickly and effectively repair tissue wounds. Subsequently, PRP was applied in various internal and external surgery, plastic surgery, skin transplantation, etc.
We previously introduced the application of PRP (Platelets Rich Plasma) in hair transplantation to help wound recovery and hair growth; Of course, the next experiment to try is to increase the coverage of primary hair by injecting PRP. Let’s see what results will be achieved by injecting autologous platelet enriched plasma and various growth factors into male patients with alopecia, which is also a therapy we can expect to use to combat hair loss.
Before and during the whole process of hair transplantation, the patients treated with PRP and those not injected with PRP can make hair grow faster. At the same time, the author also proposed a study to confirm whether platelet rich plasma has the same effect on improving fine hair. What kind of wound should be used and how much growth factor should be injected directly to be effective? Can PRP reverse the gradual thinning of hair in androgenic alopecia, or can it effectively stimulate hair growth to improve androgenic alopecia or other hair loss diseases?
In this eight month small experiment, PRP was injected into the scalp of androgenic alopecia and alopecia subjects. Compared with the control group, it can indeed reverse the gradual thinning of hair; In addition, when injected into patients with round baldness, new hair growth can be seen one month later, and the effect can last for more than eight months.
Introduction
In 2004, when one of the researchers treated the horse wound with PRP, the wound healed within one month and hair grew, and then PRP was applied to hair transplantation surgery; The researchers also tried to inject PRP on the scalp of some patients before hair transplantation, and found that the hair of the patients seemed to become thicker (1). The researchers believe that revascularization and the effect of high content of growth factor may stimulate the growth of hair follicle cells in scalp of non operation area. The blood is specially processed. Platelets are separated from other plasma proteins and contain high concentrations of platelets. To reach the standard of therapeutic effect, from 1 microliter (0.000001 liter) containing 150000-450000 platelets to 1 microliter (0.000001 liter) containing 1000000 platelets (2).
Platelet α has seven kinds of growth factors in granules, including epithelial growth factor, fibroblast growth factor, thrombogen growth factor and transforming growth factor β、 transforming growth factor α、 Interleukin-1, and vascular endothelial growth factor (VEGF). In addition, antimicrobial peptides, catecholamines, serotonin, Osteonectin, von Willebrand factor, proaccelenn and other substances are added. Thick particles have more than 100 kinds of growth factors, which can act on wounds. In addition to growth factors, the isolated platelet sparse plasma (PPP) contains three cell adhesion molecules (CAM), Fibrin, fibronectin, and vitronectin, a multifunctional protein that sets up the main structure and branches to control cell growth, adhesion, proliferation, differentiation and regeneration.
Takakura, et al. claimed that the PDCF (platelet derived growth factor) signal is related to the interaction of epidermal hair follicles and dermal stromal cells, and is necessary for the formation of hair ducts (3). In 2001, Yano et al. pointed out that VFLGF mainly regulates the hair follicle growth cycle, providing direct evidence that increasing hair follicle vascular reconstruction can promote hair growth and increase hair follicle and hair size (4).
PS: Platelet derived growth factor, PDCF. The first growth factor approved by the US FDA to treat chronic skin injury is the first growth factor released by stimulation after skin injury.
PS: Vascular endothelial growth factor, VEGF. It is one of the most important regulatory factors regulating endothelial cell proliferation, angiogenesis, vasculogenesis and vascular permeability.
If we believe that when the hair follicles have shrunk to the point where we cannot see hair growth with the naked eye, there is still a chance for hair follicles to grow hair (5). In addition, if the hair follicles of fine hairs are the same as those of coarse hairs, there are enough stem cells in the epidermis and bulge (6), it is possible to make the hair thinner and thicker in male baldness.
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Post time: Mar-15-2023